Protein-coding gene in the species Homo sapiens
Synaptosomal-associated protein 29 is a protein that in humans is encoded by the SNAP29 gene.[5][6][7]
This gene, a member of the SNAP25 gene family, encodes a protein involved in multiple membrane trafficking steps. Two other members of this gene family, SNAP23 and SNAP25, encode proteins that bind a syntaxin protein and mediate synaptic vesicle membrane docking and fusion to the plasma membrane. The protein encoded by this gene binds tightly to multiple syntaxins and is localized to intracellular membrane structures rather than to the plasma membrane. While the protein is mostly membrane-bound, a significant fraction of it is found free in the cytoplasm. Use of multiple polyadenylation sites has been noted for this gene.[7]
SNAP29 has been shown to interact with Syntaxin 3[5] and EHD1.[8]
SNAP29 was shown to interact with CVB3 and EV-D68 viral protease 3C.[9][10]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000099940 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022765 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, et al. (December 1998). "Three novel proteins of the syntaxin/SNAP-25 family". The Journal of Biological Chemistry. 273 (51): 34171–34179. doi:10.1074/jbc.273.51.34171. PMID 9852078.
- ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, et al. (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–495. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
- ^ a b "Entrez Gene: SNAP29 synaptosomal-associated protein, 29kDa".
- ^ Rotem-Yehudar R, Galperin E, Horowitz M (August 2001). "Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29". The Journal of Biological Chemistry. 276 (35): 33054–33060. doi:10.1074/jbc.M009913200. PMID 11423532.
- ^ Mohamud Y, Shi J, Qu J, Poon T, Xue YC, Deng H, et al. (March 2018). "Enteroviral Infection Inhibits Autophagic Flux via Disruption of the SNARE Complex to Enhance Viral Replication". Cell Reports. 22 (12): 3292–3303. doi:10.1016/j.celrep.2018.02.090. PMID 29562184.
- ^ Corona AK, Saulsbery HM, Corona Velazquez AF, Jackson WT (March 2018). "Enteroviruses Remodel Autophagic Trafficking through Regulation of Host SNARE Proteins to Promote Virus Replication and Cell Exit". Cell Reports. 22 (12): 3304–3314. doi:10.1016/j.celrep.2018.03.003. PMC 5894509. PMID 29562185.
- Wong SH, Xu Y, Zhang T, Griffiths G, Lowe SL, Subramaniam VN, et al. (January 1999). "GS32, a novel Golgi SNARE of 32 kDa, interacts preferentially with syntaxin 6". Molecular Biology of the Cell. 10 (1): 119–134. doi:10.1091/mbc.10.1.119. PMC 25158. PMID 9880331.
- Scales SJ, Chen YA, Yoo BY, Patel SM, Doung YC, Scheller RH (May 2000). "SNAREs contribute to the specificity of membrane fusion". Neuron. 26 (2): 457–464. doi:10.1016/S0896-6273(00)81177-0. PMID 10839363.
- Rotem-Yehudar R, Galperin E, Horowitz M (August 2001). "Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29". The Journal of Biological Chemistry. 276 (35): 33054–33060. doi:10.1074/jbc.M009913200. PMID 11423532.
- Hohenstein AC, Roche PA (July 2001). "SNAP-29 is a promiscuous syntaxin-binding SNARE". Biochemical and Biophysical Research Communications. 285 (2): 167–171. Bibcode:2001BBRC..285..167H. doi:10.1006/bbrc.2001.5141. PMID 11444821.
- Su Q, Mochida S, Tian JH, Mehta R, Sheng ZH (November 2001). "SNAP-29: a general SNARE protein that inhibits SNARE disassembly and is implicated in synaptic transmission". Proceedings of the National Academy of Sciences of the United States of America. 98 (24): 14038–14043. doi:10.1073/pnas.251532398. PMC 61163. PMID 11707603.
- Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux-Gillardeaux V, et al. (July 2003). "A dual mechanism controlling the localization and function of exocytic v-SNAREs". Proceedings of the National Academy of Sciences of the United States of America. 100 (15): 9011–9016. Bibcode:2003PNAS..100.9011M. doi:10.1073/pnas.1431910100. PMC 166429. PMID 12853575.
- Xu Y, Shi H, Wei S, Wong SH, Hong W (2005). "Mutually exclusive interactions of EHD1 with GS32 and syndapin II". Molecular Membrane Biology. 21 (4): 269–277. doi:10.1080/09687680410001716871. PMID 15371016. S2CID 22820496.
- Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10) R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
- Pan PY, Cai Q, Lin L, Lu PH, Duan S, Sheng ZH (July 2005). "SNAP-29-mediated modulation of synaptic transmission in cultured hippocampal neurons". The Journal of Biological Chemistry. 280 (27): 25769–25779. doi:10.1074/jbc.M502356200. PMC 1864940. PMID 15890653.
- Sprecher E, Ishida-Yamamoto A, Mizrahi-Koren M, Rapaport D, Goldsher D, Indelman M, et al. (August 2005). "A mutation in SNAP29, coding for a SNARE protein involved in intracellular trafficking, causes a novel neurocutaneous syndrome characterized by cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma". American Journal of Human Genetics. 77 (2): 242–251. doi:10.1086/432556. PMC 1224527. PMID 15968592.
- Carroll JS, Liu XS, Brodsky AS, Li W, Meyer CA, Szary AJ, et al. (July 2005). "Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1". Cell. 122 (1): 33–43. doi:10.1016/j.cell.2005.05.008. PMID 16009131. S2CID 16841542.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Overview of all the structural information available in the PDB for UniProt: O95721 (Synaptosomal-associated protein 29) at the PDBe-KB.
