The Indian blood group system (In) is a classification of blood based on the presence or absence of inherited antigens that reside within the CD44 molecule that is expressed on the surface of blood cells.[1] It is named so because 4% of the population in India possess it.[2] Most individuals express the Inb antigen that results from an arginine residue at position 46 of CD44 . The Ina blood type results from a substitution proline for arginine at this same position.
Clinical diagnostic
[edit]Clinical testing in patient care for Indian antigens follows published minimum quality and operational requirements,[3] similar to red cell genotyping for any of the other recognized blood group systems. Molecular analysis can identify gene variants (alleles) that may affect Indian antigens expression on the red cell membrane.
References
[edit]- ^ Telen MJ, Udani M, Washington MK, Levesque MC, Lloyd E, Rao N (March 1996). "A blood group-related polymorphism of CD44 abolishes a hyaluronan-binding consensus sequence without preventing hyaluronan binding". J. Biol. Chem. 271 (12): 7147–53. doi:10.1074/jbc.271.12.7147. PMID 8636151.
- ^ "Red Cell Antigens - Fun Facts, Questions, Answers, Information". Fun Trivia. Archived from the original on 2015-03-12. Retrieved 2014-01-03.
- ^ "Association for the Advancement of Blood & Biotherapies (AABB). (2025). Standards for molecular testing for red cell, platelet, and neutrophil antigens, 7th ed. (ISBN: 978-1-56395-516-7)".
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