Cardiotrophin 1

CTF1
Identifiers
Aliases	CTF1, cardiotrophin 1, CT-1, CT1
External IDs	OMIM: 600435; MGI: 105115; HomoloGene: 1016; GeneCards: CTF1; OMA:CTF1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)[1]
End	30,903,547 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	127,317,364 bp[2]
RNA expression pattern
	Top expressed in
	apex of heart; ; muscle of thigh; ; body of uterus; ; popliteal artery; ; tibial arteries; ; left ovary; ; right auricle of heart; ; right ovary; ; left ventricle; ; canal of the cervix;
	Top expressed in
	vestibular membrane of cochlear duct; ; Epithelium of choroid plexus; ; retinal pigment epithelium; ; epithelium of lens; ; ciliary body; ; vestibular sensory epithelium; ; muscle of thigh; ; choroid plexus of fourth ventricle; ; internal carotid artery; ; external carotid artery;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; protein binding; leukemia inhibitory factor receptor binding;
Cellular component	extracellular space; extracellular region;
Biological process	cell-cell signaling; cell surface receptor signaling pathway; muscle organ development; leukemia inhibitory factor signaling pathway; cell population proliferation; neuron development; nervous system development; positive regulation of cell population proliferation; positive regulation of tyrosine phosphorylation of STAT protein; regulation of signaling receptor activity; cytokine-mediated signaling pathway; neuron differentiation;
	Sources:Amigo / QuickGO
Orthologs
	1489
	13019
	ENSG00000150281
	ENSMUSG00000042340
	Q16619
	Q60753
	NM_001142544; NM_001330
	NM_001301282; NM_001301283; NM_007795
	NP_001136016; NP_001321
	NP_001288211; NP_001288212; NP_031821
	Wikidata
View/Edit Human	View/Edit Mouse

Cardiotrophin-1 (CT-1) is a protein encoded by the CTF1 gene in humans. It functions as a cytokine and acts as a 21.5 kDa cardiac hypertrophic factor. CT-1 belongs to the IL-6 cytokine family.

Tissue distribution

CT-1 is highly expressed in the heart, skeletal muscle, prostate and ovary and to lower levels in lung, kidney, pancreas, thymus, testis and small intestine. [5]

Mode of action

The protein exerts its cellular effects by interacting with the glycoprotein 130 (gp130)/leukemia inhibitory factor receptor beta (LIFR) heterodimer. In addition, CT-1 activates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac myocytes and enhances transcription factor NF-κB DNA -binding activities.

Clinical significance

CT-1 is associated with the pathophysiology of heart diseases, including hypertension, myocardial infarction, valvular heart disease, and congestive heart failure.

References

^ a b c GRCh38: Ensembl release 89: ENSG00000150281 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042340 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Recombinant human Cardiotrophin 1 protein (ab9838)". www.abcam.com. Retrieved 2017-08-09.

External links

cardiotrophin+1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Irving M (August 8, 2017). "The protein that can make your heart think you exercise". newatlas.com. Retrieved 2017-08-09.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000150281 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042340 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Recombinant human Cardiotrophin 1 protein (ab9838)". www.abcam.com. Retrieved 2017-08-09.